Artiklar/Studier

Pueraria Mirifica on Premenopausal Women

Clinical Study : Premenopausal Women
Product type : Pueraria mirifica Premium Grade
Function : Health Food (Food Supplement)
Test Period : 2 months

Number of Testers: 
31 Placebo
32 consumer 400 mg/day, 15 days/month
34 consumer 800 mg/day, 15 days/month

The results are summarized in following details as in below:

The placebo group contains 31 testers, had received tapioca starch filled capsule to consume 2 capsules/day for 15 days/month started from the first day of the menstruation period, for 2 consecutive months. This group showed no significance change in all record parameters.

The first tested group contains 32 testers, had received 400 mg - Pueraria mirifica filled capsule in the same condition as the placebo group. This group showed significance change with different number in all recorded parameters, including mammary pain (44%) which is related to Breast firmness and may relate also to breast enlargement, skin recovering (88%), healthier hair (75%), charisma clearance (100%), increase vaginal secretion (44%), healthier menstruation (6%), breast firmness (44%), breast enlargement (9%), and hip enlargement (9%)

The second tested group contains 34 testers, had received 800 mg - Pueraria mirifica filled capsule to consume in the same condition as the placebo group. This group showed significant change with higher number in all recorded parameters, including mammary pain (94%), skin recovering (94%), healthier hair (88%), charisma clearance (100%), increase vaginal secretion (85%), healthier menstruation (29%), breast firmness (94%), breast enlargement (88%), and hip enlargement (9%). Some subjects claimed that the high blood cholesterol levels also decreased.

Conclusion: 
In conclusion, the human test as a food supplement or functional food product has shown its estrogenic effects clearly among testers, including skin reformed, hair complexity, breast firmness, and possible to induce breast enlargement.

Puearia Mirifica - Dr. Greg Emerson 

Källa: Dr. Greg Emerson 26 August 2009

Pueraria Mirifica is a safe natural herb that blocks oestrogen receptors 3000 time more strongly than genistein from soy and stronger again than black cohosh. It is also known as Kwao Krua or Butea Superba. It is only found in Thailand and Myanmar. Mirifica means “miracle’ and this herb is at the forefront of natural herbal rejuvenation therapy. That means a dramatic reduction in the risk of both breast and prostate cancer. This herb is a phenomenal breakthrough in anti-aging medicine.

The herb contains the unique phytoestrogens miroestrol and deoxymiroestrol which are much stronger than soy, red clover and black cohosh isoflavones.

The World Health Organisation has reported that North Thailand where this herb is consumed daily has the lowest incidence of breast cancer in the world. There is also a very low incidence of osteoporosis, Alzheimers disease and benign prostatic hypertrophy.

Pueraria Mirifica has also been shown in clinical studies to enlarge the female breast however manufacturers of the herb do not push this aspect because they do not want to take the attention off the incredible potential of this herb in other areas of women’s health.

Pueraria Mirifica works by attaching itself to oestrogen receptors (an oestrogen adaptogen) and then having selective oestrogen receptor modulation (SERM) activity. What this means is the Pueraria Mirifica can bind to oestrogen receptors and stimulate them as oestrogen itself would (and is therefore useful for oestrogen deficiency symptoms) but does not have the cancer promoting effects of oestrogen. As such it works similarly to the breast cancer treatment drug tamoxifen without any of the dangerous side effects of tamoxifen. This effect on the oestrogen receptor will have a beneficial effect on diseases such as breast cancer, osteoporosis, Alzheimers disease, vaginal dryness and prostate cancer. It will also prevent oestrogen mimics such as pesticides attaching to the oestrogen receptors and inappropriately stimulating them.

Puearia Mirifica study in breast cancer

Källa: Medical Plant Research Institute Department of Medical Sciences, Ministry of Public Health, Thailand.

A series of studies involving breast cell lines and the activity of Pueraria mirifica in vitro have been performed by the Emory University School of Medicine in Atlanta, Georgia, USA, and the Department of Obstetrics and Gynecology, Phramongkutklao College of Medicine, Bangkok, Thailand. These studies have shown that Pueraria mirifica root extract has potent anti-estrogenic properties against aggressive cell cancer lines in vitro, especially the proliferative estrogen receptor-positive (ER+) breast cancer lines (T47-D, MCF-7, and ZR-75-1) obtained from the MD Anderson Cancer Institute (Texas) and the National Cancer Institute (NCI) at the U.S. National Institutes of Health (NIH).

Pueraria mirifica promotes fibroblasts in normal breast cells and inhibits estrogen-dependent breast cancer cells. Unpublished, 2001, Sawatsri, S., Juntayanee, B., Jitpatima, S., Boonnao, P., Kampoo, C., Ayuttaya, N., Wongyai, S. and Sidell, N.

According to the study conducted at the School of Medicine, Saint Mariane University, Tokyo, Japan by Kuramoshi, T. and Smitasiri, Y. about the preliminary study of Pueraria mirifica in Japanese females, 50 healthy menstruating volunteer females, ages 20 to 49, were given between 100 to 600 mg orally of Pueraria mirifica root powder daily as capsules for 7 days, two weeks after menstruation. No reports of abnormally heavy, severe, or missed menstruation were recorded.

Animal Test: There were reports during the year 1960-61 from the British researchers to test the effects of miroestrol; the key chemical from this herb in the ovariectomized and the premature female rats. The results showed the estrogenic effects of this chemical. It implied that the sythetic estrogen or animal estrogen or even human estrogen could be substituted by this chemical.

Human Test: Miroestrol has also been tested in human and was reported in 1961 as a potent estrogen effect. The Thai medical doctor has tested the crude extract in the patients in the year 1941. The result also showed the promising application of this herb.

Skin Test: Six female albino rats were hair cut and injected with 0.1% of Pueraria mirifica extract. The test was completed and showed no allergic to skin. It implied that the dermal diffsion did not cause any dermal irritation to the skin. Thus, the Pueraria mirifica extract can be presented in the cosmetics without any allergic effect.

Research and Study on Pueraria mirifica

It has been revealed recently that Pueraria mirifica is safe to be used in human in certain dosage as well as consumption period. The researcher has been conducting a series of researches covering the chemical analysis, tissue culture, mass propagation, cultivar improvement, production, product development and testing and so on for 9 years.

The result shows that Pueraria mirifica contains very high isoflavone content and shows high antimutagenic effects as well as high killing effects to human mammary cancer cell line. Nowadays, nutritionists recommend the consumer to consume isoflavone regularly for the purpose of cancer protection normally found on post-menopausal and people who have hormone imbalance.

The Benefits of Miroestrol and Its Derivatives in Pueraria mirifica Miroestrol and its derivatives are also precious chemicals in the white kwao krau which promote estrogenic and mammogenic effects to various tissues such as breast enlargement or breast tissue reformation.

The Differences between Soya and Pueraria mirifica

Soya, the western health food products, contains lower amount of phytoestrogens especially there is no miroestrol and its derivatives. Their benefit to the body is far less than that of Pueraria mirifica. The researches confirm that these chemicals are potent anti-breast cancer, anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome.

upside down, it says there is no danger as feared. Moreover, it takes effect preventing chest cancer and in addition helps build brain cells, capable of preventing Alzheimer's disease.

Pueraria mirifica clinical study in premenopausal women

The placebo group contains 31 testers, had received tapioca starch filled capsule to consume 2 capsules/day for 15 days/month started from the first day of the menstruation period, for 2 consecutive months. This group showed no significance change in all record parameters.

The first tested group contains 32 testers, had received 200 mg @ 2 capsules each per day of Pueraria mirifica filled capsule in the same condition as the placebo group.

Conclusion:
In conclusion, the human test as a food supplement or functional food product has shown its estrogenic effects clearly among testers, including skin reformed, hair complexity, breast firmness, and possible to induce breast enlargement.